Estradiol replacement therapy regulates innate immune response in ovariectomized arthritic mice

Innate Immune Responses in Mice The Tumor Suppressor ARF Regulates

Galectin-3 regulates the innate immune response of human monocytes.

Galectin-3 is a β-galactoside-binding lectin widely expressed on epithelial and hematopoietic cells, and its expression is frequently associated with a poor prognosis in cancer. Because it has not been well-studied in human infectious disease, we examined galectin-3 expression in mycobacterial infection by studying leprosy, an intracellular infection caused by Mycobacterium leprae. Galectin-3 w...

1936 Estradiol Regulates in Vitro Immune Responses

Higher serum immunoglobulin (Ig) levels are usually observed in females more than in males of several mammalian species, including man. Females also show a quantitatively and qualitatively enhanced capacity to produce antibodies after immunization (1-7). Moreover, during their fertile period, women have remarkably higher incidences of autoimmune diseases (8, 9). On the other hand, reports exist...

1936 Estradiol Regulates in Vitro Immune

Higher serum immunoglobulin (Ig) levels are usually observed in females more than in males of several mammalian species, including man. Females also show a quantitatively and qualitatively enhanced capacity to produce antibodies after immunization (1-7). Moreover, during their fertile period, women have remarkably higher incidences of autoimmune diseases (8, 9). On the other hand, reports exist...

Estradiol release kinetics determine tissue response in ovariectomized rats.

Estrogen replacement is an effective therapy of postmenopausal symptoms such as hot flushes, bone loss, and vaginal dryness. Undesired estrogen effects are the stimulation of uterine and mammary gland epithelial cell proliferation as well as hepatic estrogenicity. In this study, we examined the influence of different estradiol release kinetics on tissue responsivity in ovariectomized (OVX) rats...